EKATO
用于活性药物成分 (API) 和制药生产的加氢装置
API 生产中的加氢技术
制药行业需要灵活、易于清洁且模块化的生产解决方案。加氢是关键步骤，能够实现影响药物质量和安全性的关键化学转化。凭借超过 90 年的专业经验，EKATO 可提供根据制药需求定制的加氢装置。我们的解决方案结合了先进的混合技术、精确的控制以及全面的 GMP 合规性，确保了纯度、一致性和工艺安全。从实验室规模到商业规模，EKATO 通过可扩展、符合法规的加氢技术优化 API 生产。
API 加氢的关键参数
成功的 API 加氢依赖于多个工艺参数的精确控制，这些参数会显著影响反应结果：
- High Pressure: Typically ranging from 2-16 bar, pressure management directly affects reaction kinetics, selectivity, and operational + environmental safety considerations.
- Catalyst Type and Loading: Selection between heterogeneous (Pd/C, Pt/C, Nickel) catalysts based on reaction specificity requirements.
- Temperature Control: Precise temperature management (usually between 20-150°C) influences reaction rates and product selectivity while preventing potential side reactions.
- Mixing Efficiency: Critical for gas-liquid mass transfer, uniform catalyst distribution, and heat transfer.
- Cleanability & GMP Compliance: Process plants that are easy to clean
Free On-Demand Webinar
Are you ready to dive into the technical world of API hydrogenation?
Discover the essentials of agitated hydrogenation processes, explore innovative design concepts for agitated hydrogenation reactors, and learn about cutting-edge modular hydrogenation plant technology – all centered around API production.
Julian Urich
Project Manager Sales
EKATO Rühr- und Mischtechnik GmbH
+49 7622 29 610
julian.urich@ekato.com
Project Manager Sales
EKATO Rühr- und Mischtechnik GmbH
+49 7622 29 610
julian.urich@ekato.com
.
Process Consultation
Contact us today to connect directly with our Sales Project Manager and discover how we can enhance your process, equipment, and overall plant efficiency.
Small-Scale Hydrogenation Unit for Pharmaceuticals
Hydrogenation Reactor
Design Data
Temperature: -25 to 150 °C
Pressure: FV / 16 bar
Filling Volume: 20 to 500 L useful volume
Material Reactor: Stainless Steel, Hastelloy (C22)
Cooling: Double Jacket
Mixer: VISCOPROP or GASJET
Pharma Design: GMP and Good Cleanability
Cleaning: Includes Cleaning-in-Place (CIP)
Qualification: IQ and OQ
Gas-Liquid Reactor with Interchangeable Impeller System
Self-Aspirating turbine for volume gassing:
GASJET
- Self-aspirating impeller
- Draws gas through hollow shaft
- Re-disperses gas
- Gas is finely dispersed into liquid
- Improves mass transfer
PHASEJET
- Eliminates flat blade turbine issues under gas
- Blades shaped to reduce flow separation
- Stable power draw (gassed vs. ungassed)
- Over 2× higher flooding limit
- Boosts overall efficiency
Video
EKATO GASJET Impeller for gas-liquid applications with pure gases
Modular Process Components
Preparation Tank
- Moveable via palette trucks
- Agitator for suspending / dissolving Solids
- Available in different volumes / materials
- Optional lock for catalyst loading
Pump Station
Filter
Transfer Tank
Heating / Cooling Unit
Scrubber
Knock Out / Blow Out
Small-Scale Hydrogenation Unit
Transforming Production with Compact Modularity
- Advanced, modular hydrogenation plant tailored for pharmaceuticals (e.g. Active Pharmaceutical Ingredients (APIs), Active Diagnostic Ingredients (ADIs), small molecules, Drug Substances
- Hygienic design enables safe cleaning and prevents product cross-contamination and avoids irregular FDA audits
- Modular design allows for customizable configurations, providing tailored solutions for your production
- Designed for small and medium batch sizes
- Exceptional process flexibility and efficient production for various quantities
- Equipped with advanced safety mechanisms and automated controls for precise production processes
